Basic Information

IDDRAMP03921
SequenceKWKLFKKIGIGAVLKVLTTGLPALIS
Length26
NameCecropin A (1-8)-melittin (1-18)hybrid peptide
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-negative bacteria: Escherichia coli D21 (MIC=0.3 µM), Pseudomonas aeruginosa OT97 (MIC=0.7 µM);##Gram-positive bacteria: Bacillus subtilis Bs11 (MIC=0.4 µM), Bacillus megaterium Bm11 (MIC=0.4 µM), Staphylococcus aureus Cowan 1 (MIC=1 µM), Streptococcus pyogenes (MIC=2 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID1733777

Physicochemical Properties

Residues26
SequenceKWKLFKKIGIGAVLKVLTTGLPALIS
Molecular Weight2795.493
Grand Average of Hydropathy0.842
Isoelectric Point10.602
Charge at pH 7.44.545
Secondary StructureHelix: 0.462, Turn: 0.192, Sheet: 0.269
Instability Index-4.208
Aromaticity0.077

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.