Basic Information

IDDRAMP03935
SequenceVPIIYCNRRTGKCQRM
Length16
NameV16M (truncated isoform of thanatin, residue 6-21)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-positive bacteria: Aerococcus viridans (MIC=1.2-2.5 µM), Micrococcus luteus (MIC=2.5-5 µM), Bacillus megaterium (MIC=5-10 µM), Bacillus subtilis (MIC=20-40 µM), Pediococcus acidilactici (MIC=20-40 µM);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.6-1.2 µM), Escherichia coli D31 (MIC=0.6-1.2 µM), Klebsiella pneumoniae (MIC=2.5-5 µM), Enterobacter cloacae (MIC=5-10 µM), E. carotovora (MIC=20-40 µM).##Fungi: Neurospora crassa (MIC=10-20 µM), Botrytis cinerea (MIC=10-20 µM), Nectria haematococca (MIC=5-10 µM), Trichoderma viride (MIC=20-40 µM), Alternaria brassicicola (MIC=5-10 µM), Fusarium culmorum (MIC=10-20 µM), A. pisi (MIC=20-40 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8577744

Physicochemical Properties

Residues16
SequenceVPIIYCNRRTGKCQRM
Molecular Weight1938.348
Grand Average of Hydropathy-0.519
Isoelectric Point10.098
Charge at pH 7.43.469
Secondary StructureHelix: 0.250, Turn: 0.188, Sheet: 0.062
Instability Index41.888
Aromaticity0.062

Similar Structure Search

Candidates based on structure

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