| ID | DRAMP03936 |
|---|---|
| Sequence | KPVPIIYCNRRTGKCQRM |
| Length | 18 |
| Name | K18M (truncated isoform of thanatin, residue 4-21) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
| Pathogen | Gram-positive bacteria: Aerococcus viridans (MIC=0.6-1.2 µM), Micrococcus luteus (MIC=1.2-2.5 µM), Bacillus megaterium (MIC=2.5-5 µM), Bacillus subtilis (MIC=20-40 µM), Pediococcus acidilactici (MIC=20-40 µM);##Gram-negative bacteria: Escherichia coli D22 (MIC=0.3-0.6 µM), Escherichia coli D31 (MIC=0.3-0.6 µM), Escherichia coli 1106 (MIC=0.6-1.2 µM), Salmonella typhimuriumn (MIC=1.2-2.5 µM), Klebsiella pneumoniae (MIC=1.2-2.5 µM), Enterobacter cloacae (MIC1.2-2.5 µM), E. carotovora (MIC=20-40 µM), Pseudomonas aeruginosa (MIC=20-40 µM).##Fungi: Neurospora crassa (MIC=2.5-5 µM), Botrytis cinerea (MIC=1.2-2.5 µM), Nectria haematococca (MIC=5-10 µM), Trichoderma viride (MIC=2.5-5 µM), Alternaria brassicicola (MIC=2.5-5 µM), Fusarium culmorum (MIC=5-10 µM), A. pisi (MIC=10-20 µM), Fusarium oxysporumn (MIC=20-40 µM). |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 8577744 |
Physicochemical Properties
| Residues | 18 |
|---|---|
| Sequence | KPVPIIYCNRRTGKCQRM |
| Molecular Weight | 2163.636 |
| Grand Average of Hydropathy | -0.767 |
| Isoelectric Point | 10.321 |
| Charge at pH 7.4 | 4.501 |
| Secondary Structure | Helix: 0.222, Turn: 0.222, Sheet: 0.056 |
| Instability Index | 44.856 |
| Aromaticity | 0.056 |
