| ID | DRAMP04123 |
|---|---|
| Sequence | SGKLCCRRKK |
| Length | 10 |
| Name | D0-NH2(Derived from HBD-28 variant) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.22518150] Gram-negative bacteria: Escherichia coli (MIC=12±0.17 µM), Pseudomonas aeruginosa ATCC 27853 (MIC>100 µM);##Gram-positive bacterium: Staphylococcus aureus ATCC 25923 (MIC>100 µM). |
| Hemolytic Activity | [Ref.23860860] 2.2% hemolysis at 100 μM against human red blood cells |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 22518150, 23860860 |
Physicochemical Properties
| Residues | 10 |
|---|---|
| Sequence | SGKLCCRRKK |
| Molecular Weight | 1178.476 |
| Grand Average of Hydropathy | -1.31 |
| Isoelectric Point | 10.332 |
| Charge at pH 7.4 | 4.197 |
| Secondary Structure | Helix: 0.100, Turn: 0.200, Sheet: 0.100 |
| Instability Index | 49.3 |
| Aromaticity | 0 |