Basic Information

IDDRAMP18506
SequenceKKFFLKVLTKIRCKVAGGCRT
Length21
NameOG2 (Palustrin-OG1 peptide derivative)
SourceSynthetic construct (Modified Palustrin-OG1)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.22670762]Gram-positive bacteria: Bacillus subtilis 1A751 (MIC=128 μg/mL), Staphylococcus aureus ATCC25923 (MIC=8 μg/mL);##Gram-negative bacteria: Escherichia coli ATCC25922 (MIC=8 μg/mL),Salmonella choleraesuis CMCC50020 (MIC=16 μg/mL)
Hemolytic Activity[Ref.22670762]7%±2% hemolysis at 2-256 μg/mL against porcine red blood cells.
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22670762

Physicochemical Properties

Residues21
SequenceKKFFLKVLTKIRCKVAGGCRT
Molecular Weight2397.005
Grand Average of Hydropathy0.105
Isoelectric Point10.589
Charge at pH 7.46.496
Secondary StructureHelix: 0.333, Turn: 0.095, Sheet: 0.143
Instability Index-0.771
Aromaticity0.095

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Candidates based on structure

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