Basic Information

IDDRAMP18514
SequenceKKLALHALKKWLHALKKLAHLALKK
Length25
NameD-LAK120-H
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-, Antiplasmodial
Pathogen[Ref.22869378]Gram-negative bacteria: Escherichia coli NCTC 9001 (MIC=1.54±0.01 μM), Escherichia coli Top 10 (MIC=0.40±0.01 μM), Pseudomonas aeruginosa (MIC=1.35±0.07 μM);##Plasmodium: Plasmodium falciparum 3D7 (EC50=1.26±0.14 μM), Plasmodium falciparum C10 (EC50=4.43±0.33 μM), A549 (EC50=4.54±0.30 μM), RAW264.7 (EC50=5.21±0.57 μM)
Hemolytic Activity[Ref.22869378]HC50=20.29±2.42 μM against Not found (The literature does not mention)
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22869378

Physicochemical Properties

Residues25
SequenceKKLALHALKKWLHALKKLAHLALKK
Molecular Weight2901.672
Grand Average of Hydropathy-0.092
Isoelectric Point10.845
Charge at pH 7.47.647
Secondary StructureHelix: 0.360, Turn: 0.000, Sheet: 0.520
Instability Index-5.84
Aromaticity0.04

Similar Structure Search

Candidates based on structure

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