Basic Information

IDDRAMP18558
SequenceFIKRIARLLRKIF
Length13
NameKn2-7 (BmKn2 peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.22792229]Gram-positive bacteria: Staphylococcus aureus AB94004 (MIC=3.13 μg/ml), Staphylococcus aureus ATCC 25923 (MIC=3.13 μg/ml), Bacillus subtilis AB91021 (MIC=6.25 μg/ml), Bacillus thuringiensis AB92037 (MIC=6.25 μg/ml), Micrococcus luteus AB93113 (MIC=6.25 μg/ml);##Gram-negative bacteria: Escherichia coli AB94012 (MIC=6.25 μg/ml), Escherichia coli ATCC 25922 (MIC=25 μg/ml), Pseudomonas aeruginosa AB93066 (MIC=25 μg/ml), Pseudomonas aeruginosa A092994 (MIC=50 μg/ml), Pseudomonas aeruginosa A093052 (MIC=100 μg/ml), Pseudomonas aeruginosa A093056 (MIC=50 μg/ml), Pseudomonas aeruginosa A093085 (MIC=50 μg/ml), Pseudomonas aeruginosa A093115 (MIC=100 μg/ml).
Hemolytic Activity[Ref.22792229]Non-hemolysis at 6.25 μg/ml, 5% hemolysis at 12.5 μg/ml,10% hemolysis at 25 μg/ml 15% hemolysis at 50 μg/ml, 40% hemolysis at 100 μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22792229

Physicochemical Properties

Residues13
SequenceFIKRIARLLRKIF
Molecular Weight1674.13
Grand Average of Hydropathy0.554
Isoelectric Point12
Charge at pH 7.44.552
Secondary StructureHelix: 0.538, Turn: 0.000, Sheet: 0.231
Instability Index36.062
Aromaticity0.154

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