Basic Information

IDDRAMP21381
Sequenceaikirklfkkllr
Length13
NameSP1D * (De Novo Synthesis)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5–25 µg/mL)
Hemolytic Activity[Ref.31163671] 10% hemolysis at 25–50 μg/mL against human blood cells.
Cytotoxicity[Ref.31163671] The cell viability of Hepa 1-6 induced by SP1D is 80.4%, 102.0%, 81.8%, 81.8%, 74.3% and 66.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 μg/mL.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31163671

Physicochemical Properties

Residues13
Sequenceaikirklfkkllr
Molecular Weight1627.116
Grand Average of Hydropathy0.031
Isoelectric Point12
Charge at pH 7.45.598
Secondary StructureHelix: 0.462, Turn: 0.000, Sheet: 0.308
Instability Index-13.638
Aromaticity0.077

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