Basic Information
| ID | DRAMP20943 |
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| Sequence | FVPWFSKFLWRIL |
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| Length | 13 |
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| Name | [Pro3,DLeu9]TL(10) (Temporin L peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=1.56 μM), Staphylococcus aureus Cowan I (MIC=3.125 μM), Staphylococcus epidermidis ATCC 12228 (MIC=1.56 μM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=3.125 μM), Escherichia coli D21 (MIC=25 μM), Pseudomonas syringae pv tabaci 1918 (MIC=1.56 μM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125 μM), Candida crusei ATCC 6258 (MIC=3.125 μM) |
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| Hemolytic Activity | [Ref.28863356]37±1% hemolysis at 50μM, 20±3% hemolysis at 25μM, 7±1% hemolysis at 12.5μM, 4±2% hemolysis at 6.25μM, 2±1% hemolysis at 3.125μM against human red blood cells.##32.1 ± 2.21% cytotoxic effect at 25μM, 89.3 ± 0.8% cytotoxic effect at 50 μM on HaCaT cells. |
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| Cytotoxicity | [Ref.28863356] The cytotoxic effect is 0%, 32.1±2.21% and 89.3±0.8% at 12.5, 25 and 50 μM |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28863356 |
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