Basic Information
| ID | DRAMP21309 |
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| Sequence | FVKWWSKWLKKIL |
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| Length | 13 |
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| Name | TL-4 (Derived from Temporin-4Tl (TL)) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.26311041] Gram-positive bacteria : Bacillus subtilis (KCTC 3068)(MIC=4 μM), Staphylococcus epidermidis (KCTC 1917)(MIC=8 μM), Staphylococcus aureus (KCTC 1621)(MIC=2 μM);##Gram-negative bacteria : Escherichia coli (KCTC 1682)(MIC=8 μM), Pseudomonas aeruginosa (KCTC 1637)(MIC=16 μM), Salmonella typhimurium (KCTC 1926)(MIC=2 μM) |
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| Hemolytic Activity | [Ref.26311041] HC50=15.9 μM against human red blood cells |
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| Cytotoxicity | [Ref.26311041] The cell viability of RAW264.7 macrophages cells induced by TL-4 is 116.7%, 118.2% and 87.2% at peptide concentrations of 2.5, 5 and 10 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 26311041 |
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