Basic Information
| ID | DRAMP20941 |
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| Sequence | FVPWFSKFLKRIL |
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| Length | 13 |
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| Name | [Pro3,DLeu9]TL(8) (Temporin L peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3.125μM), Staphylococcus aureus Cowan I (MIC=6.25μM), Staphylococcus epidermidis ATCC 12228 (MIC=3.125μM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=3.125μM), Escherichia coli D21 (MIC=12.5μM), Pseudomonas syringae pv tabaci 1918 (MIC=6.25μM), Pseudomonas aeruginosa ATCC 2785 (MIC=12.5μM);##Yeasts: Candida albicans ATCC 10231 (MIC=1.56μM), Candida crusei ATCC 6258 (MIC=1.56μM) |
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| Hemolytic Activity | [Ref.28863356]49.30 ± 2.88% cytotoxic effect at 12.5 μM, 66.86 ± 2.81% cytotoxic effect at 25 μM, 96.79 ± 1.24% cytotoxic effect at 50 μM on HaCaT cells. |
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| Cytotoxicity | [Ref.28863356] The cytotoxic effect is 49.30±2.88%, 66.86±2.81% and 96.79±1.24% at peptide concentrations of 12.5, 25 and 50 μM |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28863356 |
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