Basic Information
| ID | DRAMP20833 |
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| Sequence | FVPWFSKFLGRIL |
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| Length | 13 |
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| Name | [Pro3,DLeu9]TL(1) (Temporin L peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.28863356] Gram-positive bacteria: Bacillus megaterium Bm11 (MIC=3.125μM), Staphylococcus aureus Cowan I (MIC=12.5μM), Staphylococcus epidermidis ATCC 12228 (MIC=6.25μM);##Gram-negative bacteria: Acinetobacter baumannii ATCC 19606 (MIC=12.5μM), Escherichia coli D21 (MIC=12.5μM), Pseudomonas syringae pv tabaci 1918 (MIC=12.5μM), Pseudomonas aeruginosa ATCC 2785 (MIC=50μM);##Yeasts: Candida albicans ATCC 10231 (MIC=3.125μM), Candida crusei ATCC 6258 (3.125μM). |
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| Hemolytic Activity | [Ref.28863356] 21±4% hemolysis at 50μM, 7±3% hemolysis at 25μM, 6±3% hemolysis at 12.5μM, 3±2% hemolysis at 6.25μM, 1±1% hemolysis at 3.125μM against human red blood cells.##20.63 ± 2.66% cytotoxic effect at 12.5μM, 57.52 ± 3.99% cytotoxic effect at 25μM, 91.58 ± 3.85% cytotoxic effect at 50 μM on HaCaT cells. |
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| Cytotoxicity | [Ref.28863356] The cytotoxic effects of the peptide are 20.63±2.66%, 57.52±3.99% and 91.58±3.85% at 12.5, 25 and 50 μM |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28863356 |
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