Basic Information

IDDRAMP18614
SequenceVRRFAWWWAFLRR
Length13
NameTPA (Tritrpticin peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal
Pathogen[Ref.12207877]Gram-positive bacteria: Bacillus subtilis (MIC=16 μg/ml), Staphylococcus aureus (MIC=32 μg/ml), Staphylococcus epidermidis (MIC=16 μg/ml);##Gram-negative bacteria: Escherichia coli (MIC=32 μg/ml), Salmonella typhimurium (MIC=32 μg/ml), Pseudomonas aeruginosa (MIC=64 μg/ml);##Fungus: Candida albicans (MIC=32 μg/ml).
Hemolytic Activity[Ref.12207877]18% hemolysis at 25 μg/ml, 30% hemolysis at 50 μg/ml, 62% hemolysis at 100 μg/ml, 95% hemolysis at 200 μg/ml against human red blood cells
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID12207877

Physicochemical Properties

Residues13
SequenceVRRFAWWWAFLRR
Molecular Weight1850.18
Grand Average of Hydropathy-0.269
Isoelectric Point12
Charge at pH 7.43.523
Secondary StructureHelix: 0.538, Turn: 0.000, Sheet: 0.231
Instability Index100.608
Aromaticity0.385

Similar Structure Search

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