Basic Information

IDDRAMP21389
Sequencerwirwvwrkklr
Length12
NameSP15D * (De Novo Synthesis)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=0.78–1.56 µg/mL)
Hemolytic Activity[Ref.31163671] 10% hemolysis at >100 μg/mL against human blood cells.
Cytotoxicity[Ref.31163671] The cell viability of Hepa 1-6 induced by SP15D is 91.2%, 96.6%, 96.6%, 73.6%, 58.1% and 25% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 μg/mL.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31163671

Physicochemical Properties

Residues12
Sequencerwirwvwrkklr
Molecular Weight1783.179
Grand Average of Hydropathy-1.333
Isoelectric Point12
Charge at pH 7.45.552
Secondary StructureHelix: 0.500, Turn: 0.000, Sheet: 0.083
Instability Index106.533
Aromaticity0.25

Similar Structure Search

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