Basic Information

IDDRAMP18719
SequenceDDDDDDD
Length7
NameSAAP fraction 3 (Surfactant-associated anionic peptides; Asp-rich; sheep, ruminant, mammals, animals)
SourceOvis aries
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.8552650] Gram-positive bacteria: Staphylococcus aureus ATCC 29213 (MBC50=1.21 mM in Zn-saline), Streptococcus faecalis ATCC 29213 (MBC50=1.39 mM in Zn-saline);##Gram-negative bacteria: Escherichia coli ATCC 12795 (MBC50=0.64 mM in Zn-saline), Klebsiella pneumoniae ATCC 10031 (MBC50=0.62 mM in Zn-saline), Pasteurella haemolytica (MBC50=0.02 mM in Zn-saline, MBC50=8.52 mM in Test buffer; Peptide/surfactant mixture MBC50=0.01 mM in Zn-saline, MBC50=4.43 mM in Test buffer; Peptide/serum mixture MBC50=0.02 mM in Zn-saline, MBC50=4.95 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.03 mM in Zn-saline, MBC50=2.79 mM in Test buffer).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8552650

Physicochemical Properties

Residues7
SequenceDDDDDDD
Molecular Weight823.627
Grand Average of Hydropathy-3.5
Isoelectric Point4.05
Charge at pH 7.4-7.438
Secondary StructureHelix: 0.000, Turn: 0.000, Sheet: 0.000
Instability Index8.571
Aromaticity0

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