| ID | DRAMP20827 |
|---|---|
| Sequence | FLPIVGLLKSLLK |
| Length | 13 |
| Name | TB_L1FK |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.28443279] Gram-positive bacteria: S.aureus ATCC 33591 (MIC=6μM), Staphylococcus epidermidis (MIC=1.5μM);##Gram-negative bacteria: Klebsiella pneumoniae ATCC BAA-1706 (MIC=6μM), Pseudomonas aeruginosa ATCC 27853 (MIC=6μM) |
| Hemolytic Activity | [Ref.28443279] 8% hemolysis at 48μM, 38% hemolysis at 96μM against human red cells |
| Cytotoxicity | [Ref.28443279] IC50 = 52 μM against PBMCs. ##IC50 = 59 μM against A549 cells |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Linear/Cyclic/Branched | Linear |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 28443279 |
Physicochemical Properties
| Residues | 13 |
|---|---|
| Sequence | FLPIVGLLKSLLK |
| Molecular Weight | 1440.854 |
| Grand Average of Hydropathy | 1.531 |
| Isoelectric Point | 10.003 |
| Charge at pH 7.4 | 1.552 |
| Secondary Structure | Helix: 0.615, Turn: 0.231, Sheet: 0.385 |
| Instability Index | -2.077 |
| Aromaticity | 0.077 |