Basic Information

IDDRAMP20828
SequenceKKLLPIVANLLKSLL
Length15
NameTB_KKG6A
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.28443279] Gram-positive bacteria: S.aureus ATCC 33591 (MIC=1.5μM), Staphylococcus epidermidis (MIC=1.5μM);##Gram-negative bacteria: Klebsiella pneumoniae ATCC BAA-1706 (MIC=3μM), Pseudomonas aeruginosa ATCC 27853 (MIC=3μM)
Hemolytic Activity[Ref.28443279] 11% hemolysis at 48μM, 55% hemolysis at 96μM against human red cells
Cytotoxicity[Ref.28443279] IC50 = 49 μM against PBMCs. ##IC50 = 16 μM against A549 cells
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID28443279

Physicochemical Properties

Residues15
SequenceKKLLPIVANLLKSLL
Molecular Weight1663.139
Grand Average of Hydropathy1.047
Isoelectric Point10.302
Charge at pH 7.42.55
Secondary StructureHelix: 0.533, Turn: 0.200, Sheet: 0.467
Instability Index5.193
Aromaticity0

Similar Structure Search

Candidates based on structure

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