Basic Information
| ID | DRAMP20838 |
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| Sequence | TRSRWRRFIRGAGRFARRYGWRIAL |
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| Length | 25 |
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| Name | Pb-CATH4 bivittatus antimicrobial peptides peptide derivative |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.28630199]Gram-negative bacteria:Escherichia coli (ATCC 25922)(MIC=1μg/ml);Pseudomonas aeruginosa (ATCC 27853)(MIC=3μg/ml);S. typhimurium (ATCC 14028)(MIC=0.5μg/ml);##Gram-positive bacteria:Staphylococcus aureus (ATCC 29213)(MIC>128μg/ml);B. cereus (ATCC 10876)(MIC=10μg/ml);##Clinical isolates:Escherichia coli(MIC=4.7μg/ml);K. pneumoniae(MIC=1.18μg/ml) |
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| Hemolytic Activity | [Ref.28630199] 0% hemolysis at 4μg/ml against human red blood cell; 1.4 ± 0.4% hemolysis at 8μg/ml against human red blood cell; 5.1 ± 0.5% hemolysis at 16μg/ml against human red blood cell;7.3 ± 0.6% hemolysis at 32μg/ml against human red blood cell; 12.2 ± 0.7% hemolysis at 64μg/ml against human red blood cell |
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| Cytotoxicity | [Ref.28630199] The cell viability of Pk15(pig kidney fibroblasts) is 103.8%, 124.6%, 94.7%,55.2% and 53.9% at peptide concentrations of 5, 10, 20, 30 and 64 μg/ml. ##The cell viability of HaCaT(human keratinocytes) is 106.9%, 94.6%, 66.2%, 58.1% and 51. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28630199 |
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