Basic Information

IDDRAMP20871
SequenceGLLKRIK
Length7
NamePal-ano-7 (Pal-anoplin peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=0.813 μg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=1.63 μg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=13 μg/mL).
Hemolytic Activity[Ref.29614317] HC50=37.70μg/mL against human red blood cells
Cytotoxicity[Ref.29614319] No cytotoxicity information found
N-terminal ModificationAcylation (Gly1 conjugated with a palmitoyl group)
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29614317

Physicochemical Properties

Residues7
SequenceGLLKRIK
Molecular Weight827.07
Grand Average of Hydropathy-0.086
Isoelectric Point11.166
Charge at pH 7.42.552
Secondary StructureHelix: 0.429, Turn: 0.143, Sheet: 0.286
Instability Index30.886
Aromaticity0

Similar Structure Search

Candidates based on structure

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