Basic Information

IDDRAMP20873
SequenceGLLKR
Length5
NamePal-ano-5 (Pal-anoplin peptide derivative)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29614317] Gram-positive bacteria: Staphylococcus aureus ATCC 25923 (MIC=3.25 μg/mL);##Gram-negative bacteria: Escherichia coli ATCC 25922 (MIC=6.5 μg/mL);##Fungi: Candida albicans ATCC 10231 (MIC=13 μg/mL).
Hemolytic Activity[Ref.29614317] HC50= 66.12μg/mL against human red blood cells
Cytotoxicity[Ref.29614321] No cytotoxicity information found
N-terminal ModificationAcylation (Gly1 conjugated with a palmitoyl group)
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29614317

Physicochemical Properties

Residues5
SequenceGLLKR
Molecular Weight585.74
Grand Average of Hydropathy-0.24
Isoelectric Point11.001
Charge at pH 7.41.555
Secondary StructureHelix: 0.400, Turn: 0.200, Sheet: 0.400
Instability Index56.22
Aromaticity0

Similar Structure Search

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