Basic Information

IDDRAMP20881
SequenceVTCDLLSAEAKGVKVNHAACAAHCLLKRKRGGYCNKRRICVCRN
Length44
NameHOLO1
SourceRed flour beetle (Tribolium castaneum)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Antifungal
Pathogen[Ref.29501691] Gram-positive bacteria: Staphylococcus aureus (MIC=13.2μ±μ1.8 μg/mL), Bacillus subtilis (MIC=6μ±μ1.8 μg/mL);##Fungi: Candida albicans (MIC=4.6μ±μ1.1 μg/mL)
Hemolytic Activity[Ref.29501691] 0% haemolysis at 10 μg/ml, 0% haemolysis at 25 μg/ml, 0% haemolysis at 50 μg/ml, 0% haemolysis at 100 μg/ml, 0% haemolysis at 200 μg/ml against sheep red blood cells
Cytotoxicity[Ref.29501691] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot D6X2G2
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29501691

Physicochemical Properties

Residues44
SequenceVTCDLLSAEAKGVKVNHAACAAHCLLKRKRGGYCNKRRICVCRN
Molecular Weight4830.738
Grand Average of Hydropathy-0.173
Isoelectric Point9.695
Charge at pH 7.47.436
Secondary StructureHelix: 0.227, Turn: 0.159, Sheet: 0.250
Instability Index58.875
Aromaticity0.023

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