Basic Information

IDDRAMP20907
SequenceIIGGLFSAGKAIHRLIRRRRR
Length21
NamedN4
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.29040295] Gram-positive bacteria: Staphylococcus aureus (MIC=128 μg/ml; MBC=128 μg/ml), Methicillin-resistant Staphylococcus aureus (MIC=64 μg/ml; MBC=256 μg/ml);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=256 μg/ml; MBC>512 μg/ml);##Fungi: Candida albicans (MIC=64 μg/ml; MBC=128 μg/ml)
Hemolytic Activity[Ref.29040295] 10% haemolysis haemolysis at 12.50 μg/ml, 12% haemolysis haemolysis at 25.00 μg/ml, 20% haemolysis haemolysis at 50.00 μg/ml, 35% haemolysis haemolysis at 100.00 μg/ml, 75% haemolysis haemolysis at 200.00 μg/ml, 100% haemolysis haemolysis at 400.00 μg/ml, 100% haemolysis haemolysis at 800.00 μg/ml against mouse red blood cells
Cytotoxicity[Ref.29040295] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID29040295

Physicochemical Properties

Residues21
SequenceIIGGLFSAGKAIHRLIRRRRR
Molecular Weight2446.948
Grand Average of Hydropathy-0.195
Isoelectric Point12
Charge at pH 7.46.591
Secondary StructureHelix: 0.333, Turn: 0.190, Sheet: 0.190
Instability Index126.338
Aromaticity0.048

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