Basic Information
| ID | DRAMP20935 |
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| Sequence | GFGMALKLLKKVL |
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| Length | 13 |
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| Name | Macropin 1(solitary bee, insects, animals) |
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| Source | Macropis fulvipes (Solitary bee) (Megilla fulvipes) |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
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| Pathogen | [Ref.24616110] Gram-negative bacteria: Escherichia coli(MIC=3.0 μM), Pseudomonas aeruginosa(MIC=35.0 μM);## Gram-positive bacteria: Bacillus subtilis (MIC=1.3 μM), Staphylococcus aureus(MIC=3.7 μM);## Fungus: Candida albicans (MIC=6.3 μM). ##[Ref.29185466]Gram-positive bacteria:Staphylococcus aureus ATCC 25923 (MIC=3.13 μM), Staphylococcus aureus ATCC 29213 (MIC=3.13 μM), Listeria monocytogenes KCTC 3710 (MIC=25 μM);##Gram-negative bacteria: Pseudomonas aeruginosa ATCC 27853 (MIC=6.25 μM), Pseudomonas aeruginosa ATCC 15692 (MIC=6.25 μM), Escherichia coli ATCC 25922 (MIC=6.25 μM) |
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| Hemolytic Activity | [Ref.24616110] LC50=160 μM against human red blood cells. ##[Ref.29185466]5% hemolysis at 25 μM against red blood cells, 93% hemolysis at 50 μM against red blood cells |
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| Cytotoxicity | [Ref.29185466] In HaCaT cells, Macropin produced cell survival rates of 82% and 41% at peptide concentrations of 25 and 50 μM.## In Raw cells, Macropin produce cell survival rates of 41% and 0% at peptide concentrations of 25 and 50 μM. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
C0HL98 |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 24616110, 29185466 |
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