ABPDB

Basic Information

ID	DRAMP20963
Sequence	LRLKKYKVPQL
Length	11
Name	Cp1 alpha s1-casein peptide derivative
Source	Synthetic construct
Activity	Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, low hemolytic and toxic effects
Pathogen	[Ref.29783753] Gram-negative bacteria: Escherichia coli (ATCC 25922)(MIC=64μM);Escherichia coli (UB1005)(MIC=128μM);Salmonella pullorum (C7913)(MIC=256μM);Salmonella enterica subsp enterica (CMCC 50071)(MIC=256μM);##Gram-positive bacteria: Staphylococcus aureus (ATCC 29213)(MIC=640μM);L. monocytogenes (CMCC 54004)(MIC=64μM)
Hemolytic Activity	[Ref.2978375]Hemolysis 0% at 16μM;Hemolysis 23.54% at 512μM against human red blood cells
Cytotoxicity	[Ref.29783753] In 293 cells, The peptide had no cytotoxic activity at concentrations of 1-512 μM. The cell survival rates are 100%, 96%, 98%, 105%, 104%, 112%, 116%, 114% and 103% at concentrations of 1, 2, 4, 8, 16, 32, 64, 128, 256, 512 μM
N-terminal Modification	Free
C-terminal Modification	Amidation
Linear/Cyclic/Branched	Linear
Uniprot
PDB
3D View
PDB Download	Download PDB Predicted by Alphafold2
PubMed ID	29783753

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