Basic Information

IDDRAMP20965
SequenceMNKVKEWIKYLKSLFSM
Length17
NameLPcin-YK3 (bovine cathelicidin, cattle, ruminant, mammals, animals)
SourceBovine Lactophoricin
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.30021422] Gram-positive bacteria : Streptococcus mutans KCCM 40105 (MIC=1.25 μg/ml), Propionibacteria acnes KCCM 41747 (MIC=1.25 μg/ml), Staphylococcus aureus KCTC 1621 (MIC=0.62 μg/ml);##Gram-negative bacteria : Porphyromonas gingvalis KCTC 5352 (MIC=0.62 μg/ml), Escherichia coli KCCM 41290 (MIC=1.25 μg/ml);##Fungi : Candida albicans KCTC 17712 (MIC=10.0 μg/ml)
Hemolytic Activity[Ref.30021422] 0% hemolysis at 40 μg/ml against mouse red blood cell
Cytotoxicity[Ref.30021422] No cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID30021422

Physicochemical Properties

Residues17
SequenceMNKVKEWIKYLKSLFSM
Molecular Weight2145.628
Grand Average of Hydropathy-0.206
Isoelectric Point9.824
Charge at pH 7.42.273
Secondary StructureHelix: 0.412, Turn: 0.176, Sheet: 0.294
Instability Index-2.176
Aromaticity0.176

Similar Structure Search

Candidates based on structure

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