Basic Information
| ID | DRAMP20967 |
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| Sequence | AIGHCLGATL |
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| Length | 10 |
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| Name | andricin 01 (Andrias davidianus, Amphibians, Animals) |
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| Source | Andrias davidianus |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.28461043] Gram-positive bacteria : Bacillus subtilis CICC 10034 (MIC=32 μg/ml;MBC=32 μg/ml), Bacillus megaterium CICC 10448 (MIC=8 μg/ml;MBC=16 μg/ml), Staphylococcus aureus CICC 10306 (MIC=32 μg/ml;MBC=32 μg/ml), Staphylococcus aureus CICC 10384 (MIC=32 μg/ml;MBC=32 μg/ml), Listeria innocua CICC 10417 (MIC=32 μg/ml;MBC=32 μg/ml);##Gram-negative bacteria : Escherichia coli CICC 10293 (MIC=8 μg/ml;MBC=16 μg/ml), Escherichia coli CGMCC 3373 (MIC=8 μg/ml;MBC=16 μg/ml), Escherichia coli CICC 10302 (MIC=8 μg/ml;MBC=16 μg/ml), Escherichia coli CICC 10300 (MIC=8 μg/ml;MBC=16 μg/ml), Pseudomonas aeruginosa CICC 21636 (MIC=4 μg/ml;MBC=8 μg/ml), Alcaligenes faecalis ATCC 8750 (MIC=8 μg/ml;MBC=16 μg/ml), Serratia marcescens ATCC 4112 (MIC=8 μg/ml;MBC=8 μg/ml), Enterobacter cloacae CICC 21539 (MIC=4 μg/ml;MBC=8 μg/ml), Salmonella Paratyphi CICC 10437 (MIC=8 μg/ml;MBC=16 μg/ml) |
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| Hemolytic Activity | [Ref.28461043] 0% hemolysis at 25 μg/ml , 0% hemolysis at 50 μg/ml , 4.3 ± 0.16% hemolysis at 100 μg/ml , 16.3 ± 2.16% hemolysis at 200 μg/ml against human hepatocyte cell line and human renal epithelial cells;0% hemolysis at 0–50 μg/ml against human red blood cells |
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| Cytotoxicity | [Ref.28461043] The cell viability of HL-7702 cells is 100.0±0.30%, 100.5±0.52%, 86.8±2.10% and 52.1±1.81% at peptide concentrations of 25, 50, 100 and 200 μg/ml. ##The cell viability of HREpiC cells is 100.1±0.20%, 103.1±1.20%, 82.3±1.84% and 50.3±2.05% |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 28461043 |
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