Basic Information
| ID | DRAMP20976 |
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| Sequence | RKYVRFLHRWVKYFRAYL |
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| Length | 18 |
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| Name | adevonin (Derived from Adenanthera pavonina trypsin inhibitor (ApTI))
inhibitor (ApTI)) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.30570384]Gram-positive bacteria : Staphylococcus aureus ATCC 80958 (MIC=7.35 μM);##Gram-negative bacteria : Escherichia coli ATCC 35218 (MIC=7.35 μM), Klebsiella oxytoca ATCC 13182 (MIC=1.84 μM), Klebsiella pneumoniae ATCC 70603 (MIC=3.67 μM), Serratia marcesens ATCC 13880 (MIC=1.84 μM), Klebsiella pneumoniae KpC+ 001825971 (MIC=25.6 μM) |
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| Hemolytic Activity | [Ref.30570384] 0% hemolysis at 43.75 μM , 72.5% hemolysis at 175 μM , 77% hemolysis at 350 μg/ml against human type O erythrocytes |
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| Cytotoxicity | [Ref.30570384] In fibroblasts, a significant reduction of cell viability, of 25% on average, is observed in each time interval(24,48 and 72h) in the highest peptide concentration(10 μM) |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 30570384 |
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