Basic Information

IDDRAMP21083
SequenceKWCRCVCRRGICRCFCRG
Length18
NameccTP 5 (Derived from TP2)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.10673369] Gram-positive bacteria : Staphylococcus aureus(MIC=1.7 μM(low-salt);MIC=1.3 μM(high-salt)), Micrococcus luteus(MIC=0.5 μM(low-salt);MIC=0.8 μM(high-salt)), Enterococcus faecalis(MIC=0.7 μM(low-salt);MIC=0.5 μM(high-salt));##Gram-negative bacteria : Escherichia coli(MIC=5.5 μM(low-salt);MIC=1.2 μM(high-salt)), Pseudomonas aeruginosa(MIC=3.9 μM(low-salt);MIC=4.7 μM(high-salt)), Primula vulgaris(MIC=16.8 μM(low-salt);MIC=55.6 μM(high-salt)), Klebsiella oxytoca(MIC=2.4 μM(low-salt);MIC=5.4 μM(high-salt));##Fungi : Candida albicans(MIC=7.1 μM(low-salt);MIC=5.1 μM(high-salt)), Candida kefyr(MIC=4.2 μM(low-salt);MIC=0.7 μM(high-salt)), Candida tropicalis(MIC=1.9 μM(low-salt);MIC=4.8 μM(high-salt))
Hemolytic Activity[Ref.10673369] EC25=920 μM against human red blood cells
Cytotoxicity[Ref.10673369] No cytotoxicity information found.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10673369

Physicochemical Properties

Residues18
SequenceKWCRCVCRRGICRCFCRG
Molecular Weight2205.748
Grand Average of Hydropathy-0.089
Isoelectric Point9.567
Charge at pH 7.45.408
Secondary StructureHelix: 0.222, Turn: 0.111, Sheet: 0.000
Instability Index22.928
Aromaticity0.111

Similar Structure Search

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