Basic Information
| ID | DRAMP18585 |
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| Sequence | KWCRCVCRRGICYCRCRG |
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| Length | 18 |
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| Name | [Arg4,8]ccTP (ccTP peptide derivative) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anitifungal |
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| Pathogen | [Ref.10673369]Gram-positive bacteria: Staphylococcus aureus (MIC=1.3 μM in low-salt; MIC=0.3 μM in high-salt), Micrococcus luteus (MIC=0.5 μM in low-salt; MIC=0.7 μM in high-salt), Enterococcus faecalis (MIC=1.0 μM in low-salt; MIC=1.2 μM in high-salt);##Gram-negative bacteria: Escherichia coli (MIC=9.8 μM in low-salt; MIC=2.0 μM in high-salt), Pseudomonas aeruginosa (MIC=8.0 μM in low-salt; MIC=5.3 μM in high-salt), Primula vulgaris (MIC=26.7 μM in low-salt; MIC=56.2 μM in high-salt), Klebsiella oxytoca (MIC=6.1 μM in low-salt; MIC=7.8 μM in high-salt);##Fungi: Candida albicans (MIC=6.4 μM in low-salt; MIC=11.2 μM in high-salt), Candida kefyr (MIC=1.1 μM in low-salt; MIC=1.9 μM in high-salt), Candida tropicalis (MIC=2.8 μM in low-salt; MIC=4.2 μM in high-salt). |
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| Hemolytic Activity | [Ref.10673369] EC25=910 μM against human red blood cells |
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| Cytotoxicity | No cytotoxicity information found |
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| N-terminal Modification | No specific N-terminal |
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| C-terminal Modification | No specific C-terminal |
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| Linear/Cyclic/Branched | Cyclic |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 10673369 |
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