Basic Information

IDDRAMP02642
SequenceGFCRCLCRRGVCRCICTR
Length18
NameRhesus theta-defensin 1 (RTD-1; primates, mammals, animals)
SourceMacaca mulatta (Rhesus macaque)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral
PathogenGram-positive bacteria: Staphylococcus aureus 502a and Listeria monocytogenes;##Gram-negative bacteria: Salmonella typhimurium, Escherichia coli ML35.##Fungi: Candida albicans 16820, Cryptococcus neoformans 271A (the activity of RTD-2 against Escherichia coli ML35 was 2-3-fold less than those of RTD-1 and RTD-3).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNo cytotoxicity information found
N-terminal ModificationNo specific N-terminal
C-terminal ModificationNo specific C-terminal
Linear/Cyclic/BranchedCyclic
Uniprot P82271, P82270, Q9TU01
PDB 1HVZ
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10521339, 1152799, 11675394

Physicochemical Properties

Residues18
SequenceGFCRCLCRRGVCRCICTR
Molecular Weight2105.628
Grand Average of Hydropathy0.35
Isoelectric Point9.303
Charge at pH 7.44.41
Secondary StructureHelix: 0.222, Turn: 0.111, Sheet: 0.056
Instability Index65.361
Aromaticity0.056

Similar Structure Search

Candidates based on structure

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