Basic Information
| ID | DRAMP21086 |
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| Sequence | RFRRLRWKTRWRLKKIRFGRFLRKIRRFRPK |
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| Length | 31 |
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| Name | PR-FO (Derived from PRW4) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.25818457] Gram-positive bacteria : Staphylococcus aureus 25923(MIC=8.6 mg/L), Staphylococcus aureus 29213(MIC=4.3 mg/L), Staphylococcus epidermidis 12228(MIC=2.2 mg/L), Enterococcus faecalis 29212(MIC=1.1 mg/L), Bacillus subtilis 11060(MIC=2.2 mg/L);##Gram-negative bacteria : Escherichia coli 078(MIC=2.2 mg/L), Escherichia coli K88(MIC=4.3 mg/L), Escherichia coli ER2566(MIC=2.2 mg/L), Escherichia coli 44102(MIC=8.6 mg/L), Escherichia coli 1515(MIC=2.2 mg/L), Escherichia coli 25922(MIC=2.2 mg/L), Escherichia coli UB1005(MIC=4.3 mg/L), Salmonella typhimurium 7731(MIC=0.5 mg/L), Salmonella typhimurium 1402(MIC=8.6 mg/L), Pseudomonas aeruginosa 21625(MIC=8.6 mg/L), Pseudomonas aeruginosa 21630(MIC=0.5 mg/L), Pseudomonas aeruginosa 10419(MIC=4.3 mg/L), Pseudomonas aeruginosa 27853(MIC=8.6 mg/L), Salmonella pullorum 7913(MIC=8.6 mg/L) |
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| Hemolytic Activity | [Ref.25818457] 0% hemolysis at 9.2 mg/L , 1% hemolysis at 18.4 mg/L , 4% hemolysis at 36.8mg/L , 5% hemolysis at 73.6 mg/L , 10% hemolysis at 147.1 mg/L , 13% hemolysis at 294.3 mg/L against human red blood cells |
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| Cytotoxicity | [Ref.25818457] The cell viability of PR-FO is 93%, 89%, 84%, 79%, 74%, 69%, 67%, 64% and 62% at peptide concentrations of 1.1, 2.3, 4.6, 9.2, 18.4, 36.8, 73.6, 147.1 and 294.3 μg/ml. |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 25818457 |
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