Basic Information
| ID | DRAMP21103 |
|---|
| Sequence | RWTWRGSGRWTWR |
|---|
| Length | 13 |
|---|
| Name | L-RW (De novo synthesis) |
|---|
| Source | Synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
|---|
| Pathogen | [Ref.25683050] Gram-positive bacteria : Staphylococcus aureus(MIC=8 μg/ml), Micrococcus luteus(MIC=16 μg/ml), Bacillus subtilis(MIC=16 μg/ml);##Gram-negative bacteria : Escherichia coli(MIC=16 μg/ml), Pseudomonas aeruginosa(MIC=125 μg/ml), Acinetobacter baumannii(MIC=32 μg/ml), Stenotrophomonas maltophilia(MIC>500 μg/ml) |
|---|
| Hemolytic Activity | [Ref.25683050] 0% hemolysis at 8 mg/L , 3.25% hemolysis at 16 mg/L , 0% hemolysis at 32mg/L , 0% hemolysis at 64 mg/L , 0% hemolysis at 125 mg/L , 0% hemolysis at mg/L , 2.5% hemolysis at 500 mg/L against rabbit red blood cells |
|---|
| Cytotoxicity | [Ref.25683050] The inhibition ratio of I-RW against human bronchial epithelial cell line BEAS-2B cells is 11.3%, 2.1%, 0.5%, 6.2%, 1.5%, 8.2%, 37.4% and 51.8% at peptide concentrations of 2.5, 5, 10, 20, 40, 80, 160 and 320 μg/ml |
|---|
| N-terminal Modification | Acylation (Conjugated with acetyl group) |
|---|
| C-terminal Modification | Amidation |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 25683050 |
|---|
