| ID | DRAMP21126 |
|---|---|
| Sequence | RFRRLRKKIRKRLKKI |
| Length | 16 |
| Name | T9I (Derived from RI16) |
| Source | Synthetic construct |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
| Pathogen | [Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=256 μM), Staphylococcus epidermidis 12228(MIC=32 μM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=128 μM), Salmonella typhimurium 7731(MIC=256 μM), Pseudomonas aeruginosa 27853(MIC=256 μM), Pseudomonas aeruginosa 10419(MIC=256 μM), Pseudomonas aeruginosa 21625(MIC=256 μM), Pseudomonas aeruginosa 21630(MIC=256 μM), Pseudomonas aeruginosa LC(MIC=64 μM), Pseudomonas aeruginosa LCCI(MIC=256 μM), Pseudomonas aeruginosa LCGE(MIC=256 μM), Pseudomonas aeruginosa LCCE(MIC=256 μM) |
| Hemolytic Activity | [Ref.25494332] HC50>256 μM against human red blood cells |
| Cytotoxicity | [Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 μM |
| N-terminal Modification | Free |
| C-terminal Modification | Amidation |
| Linear/Cyclic/Branched | Linear |
| Uniprot | |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 25494332 |
Physicochemical Properties
| Residues | 16 |
|---|---|
| Sequence | RFRRLRKKIRKRLKKI |
| Molecular Weight | 2195.795 |
| Grand Average of Hydropathy | -1.694 |
| Isoelectric Point | 12 |
| Charge at pH 7.4 | 10.545 |
| Secondary Structure | Helix: 0.312, Turn: 0.000, Sheet: 0.125 |
| Instability Index | 61.669 |
| Aromaticity | 0.062 |
