Basic Information

IDDRAMP21385
SequenceIRRRIRLIVRRQI
Length13
NameSP12 (De Novo Synthesis)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=12.5–25 µg/mL)
Hemolytic Activity[Ref.31163671] 10% hemolysis at >100 μg/mL against human blood cells.
Cytotoxicity[Ref.31163671] The cell viability of Hepa 1-6 induced by SP12 is 98.0%, 99.3%, 95.9%, 92.6%, 100% and 89.2% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 μg/mL.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31163671

Physicochemical Properties

Residues13
SequenceIRRRIRLIVRRQI
Molecular Weight1748.178
Grand Average of Hydropathy-0.346
Isoelectric Point12
Charge at pH 7.45.557
Secondary StructureHelix: 0.462, Turn: 0.000, Sheet: 0.077
Instability Index149.7
Aromaticity0

Similar Structure Search

Candidates based on structure

Address: No.2699 Qianjin Street, Changchun City, China. Zip Code: 130012. 苏ICP备2021057230号-1.