Basic Information

IDDRAMP21127
SequenceRFRRLRKKKRKRLKKI
Length16
NameT9K (Derived from RI16)
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.25494332] Gram-positive bacteria : Staphylococcus aureus 29213(MIC=128 μM), Staphylococcus epidermidis 12228(MIC=128 μM), ;##Gram-negative bacteria : Escherichia coli 25922(MIC=128 μM), Salmonella typhimurium 7731(MIC=256 μM), Pseudomonas aeruginosa 27853(MIC=128 μM), Pseudomonas aeruginosa 10419(MIC=256 μM), Pseudomonas aeruginosa 21625(MIC=256 μM), Pseudomonas aeruginosa 21630(MIC=256 μM), Pseudomonas aeruginosa LC(MIC=256 μM), Pseudomonas aeruginosa LCCI(MIC=256 μM), Pseudomonas aeruginosa LCGE(MIC=256 μM), Pseudomonas aeruginosa LCCE(MIC=256 μM)
Hemolytic Activity[Ref.25494332] HC50>256 μM against human red blood cells
Cytotoxicity[Ref.25494332] The LD50 of J774.1 macrophage cells is larger than 256 μM
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID25494332

Physicochemical Properties

Residues16
SequenceRFRRLRKKKRKRLKKI
Molecular Weight2210.81
Grand Average of Hydropathy-2.219
Isoelectric Point12
Charge at pH 7.411.542
Secondary StructureHelix: 0.250, Turn: 0.000, Sheet: 0.125
Instability Index87.35
Aromaticity0.062

Similar Structure Search

Candidates based on structure

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