Basic Information
| ID | DRAMP21142 |
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| Sequence | HKCAKIKWRGVHVKYCA |
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| Length | 17 |
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| Name | AMP2041 (De novo synthesis) |
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| Source | Synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.23893489] Gram-positive bacteria : Staphylococcus aureus(MBC=3.71 μg/ml, 1.83 μM), MRSA(MBC=2.25 μg/ml, 1.11 μM), Streptococcus agalactiae(MBC>100 μg/ml, 55 μM);##Gram-negative bacteria : Pseudomonas aeruginosa(MBC=4.35 μg/ml, 2.14 μM), Escherichia coli(MBC=1.79 μg/ml, 0.88 μM), Salmonella enteritidis(MBC=10.41 μg/ml, 5.13 μM), Stenotrophomonas maltophilia(MBC=7.00 μg/ml, 3.45 μM) |
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| Hemolytic Activity | [Ref.23893489] <1% hemolysis at 1 μg/ml , <1% hemolysis at 12.5 μg/ml , 5.73% hemolysis at 100 μg/ml , 6.4% hemolysis at 250 μg/ml , 9.4% hemolysis at 500 μg/ml against sheep red blood cells |
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| Cytotoxicity | [Ref.23893489] The cytotoxicity (vs control) of P2041 is 6% against HUVEC (endothelial) cells at a peptide concentration of 100 μg/ml. ##The cytotoxicity (vs control) of P2041 is 3% agaisnt WI-38 (fibroblast) cells at a peptide concentration of 100 μg/m |
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| N-terminal Modification | Free |
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| C-terminal Modification | Free |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 23893489 |
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