Basic Information
| ID | DRAMP21310 |
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| Sequence | RRLRKKTRKRLK |
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| Length | 12 |
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| Name | RK12 (Derived from PMAP-36) |
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| Source | synthetic construct |
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| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
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| Pathogen | [Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC>128 μM), Staphylococcus aureus 25923 (MIC>128 μM), Staphylococcus epidermidis 12228 (MIC>128 μM);##Gram-negative bacteria: Escherichia coli 25922 (MIC>128 μM), Escherichia coli 1005 (MIC=64 μM), Staphylococcus typhi (MIC>128 μM) |
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| Hemolytic Activity | [Ref.31276398] MHC>128μM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs). |
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| Cytotoxicity | [Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RK12 is 91.7%, 96.2%, 95.2%, 95.3%, 96.2%, 94.7%, 98.8% and 99.3% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 μM |
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| N-terminal Modification | Free |
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| C-terminal Modification | Amidation |
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| Linear/Cyclic/Branched | Linear |
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| Uniprot |
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| PDB |
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| 3D View | |
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| PDB Download | Download PDB Predicted by Alphafold2 |
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| PubMed ID | 31276398 |
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