Basic Information
| ID | DRAMP21319 |
|---|
| Sequence | VRLRVKTRVRLK |
|---|
| Length | 12 |
|---|
| Name | 3V (Derived from PMAP-36) |
|---|
| Source | synthetic construct |
|---|
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram- |
|---|
| Pathogen | [Ref.31276398] Gram-positive bacteria:Staphylococcus aureus 29213 (MIC=16 μM), Staphylococcus aureus 25923 (MIC=64 μM), Staphylococcus epidermidis 12228 (MIC=32 μM);##Gram-negative bacteria: Escherichia coli 25922 (MIC=4 μM), Escherichia coli 1005 (MIC=4 μM), Staphylococcus typhi (MIC=16 μM) |
|---|
| Hemolytic Activity | [Ref.31276398] MHC>128μM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs). |
|---|
| Cytotoxicity | [Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by 3V is 98.6%, 101.4%, 103.4%, 92.4%, 101%, 101.9%, 93.6% and 97.4% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 μM |
|---|
| N-terminal Modification | Free |
|---|
| C-terminal Modification | Amidation |
|---|
| Linear/Cyclic/Branched | Linear |
|---|
| Uniprot |
|
|---|
| PDB |
|
|---|
| 3D View | |
|---|
| PDB Download | Download PDB Predicted by Alphafold2 |
|---|
| PubMed ID | 31276398 |
|---|
