Basic Information

IDDRAMP21378
SequenceRLFIKKLKFITRR
Length13
NameSP6 (De Novo Synthesis)
Sourcesynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.31163671] Gram-negative bacteria:Escherichia coli ATCC 25922 (MIC=25–50 µg/mL)
Hemolytic Activity[Ref.31163671] 10% hemolysis at >100 μg/mL against human blood cells.
Cytotoxicity[Ref.31163671] The cell viability of Hepa 1-6 induced by SP6 is 92.6%, 100%, 102.7%, 106.8%, 93.2% and 99.3% at peptide concentrations of 3.125, 6.25, 12.5, 25, 50 and 100 μg/mL.
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID31163671

Physicochemical Properties

Residues13
SequenceRLFIKKLKFITRR
Molecular Weight1719.171
Grand Average of Hydropathy-0.285
Isoelectric Point12
Charge at pH 7.45.55
Secondary StructureHelix: 0.462, Turn: 0.000, Sheet: 0.154
Instability Index33.7
Aromaticity0.154

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