Basic Information

IDDRAMP29087
SequenceVRLIVKVRIWRR
Length12
NameRiLK1
SourceSynthetic construct
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Ref.32971824] Gram-negative bacteria: E.coli (IC50 = 1.20 ± 0.10 μM, MBC = 2.0 μM), S. Typhimurium (IC50 = 1.30 ± 0.14 μM, MBC = 2.5 μM);##Gram-positive bacteria: S. aureus (IC50 = 1.98 ± 0.25 μM, MBC = 16.0 μM), L. monocytogenes (IC50 = 0.46 ± 0.01 μM, MBC = 2.0 μM);##Fungi: C. albicans ATCC 14053, A. brasiliensis ATCC 9341. Susceptibility testing clearly showed that RiLK1 was very effective, being able to inhibit 100% growth of both fungi at 25 μM concentration (MFC).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.32971824] It was observed that the cell viability was recorded as 98%, 98.7%, and 98.9% at the concentrations of RiLK1 (10, 25, 50 μM)
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID32971824

Physicochemical Properties

Residues12
SequenceVRLIVKVRIWRR
Molecular Weight1594.006
Grand Average of Hydropathy0.217
Isoelectric Point12
Charge at pH 7.44.521
Secondary StructureHelix: 0.583, Turn: 0.000, Sheet: 0.083
Instability Index40.35
Aromaticity0.083

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