Basic Information

IDDRAMP00767
SequenceGDACGETCFTGICFTAGCSCNPWPTCTRN
Length29
NameChaC1 (Chassatide C1; Plant defensin)
SourceChassalia chartacea
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Anti-cancer
PathogenGram-negative bacterium: Escherichia coli (MIC>80 µM);##Gram-positive bacteria: Staphylococcus aureus (MIC>80 µM), Staphylococcus epidermidis (MIC>80 µM).
Hemolytic Activity[Ref.22467870] HD50=51.9 µM against human type A red blood cells.
Cytotoxicity[Ref.22467870] Cytotoxicity: HeLa cells (IC50=9.8 µM).
N-terminal ModificationNo specific N-terminal
C-terminal ModificationNo specific C-terminal
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID22467870

Physicochemical Properties

Residues29
SequenceGDACGETCFTGICFTAGCSCNPWPTCTRN
Molecular Weight3016.368
Grand Average of Hydropathy0.007
Isoelectric Point4.37
Charge at pH 7.4-1.588
Secondary StructureHelix: 0.138, Turn: 0.310, Sheet: 0.103
Instability Index41.103
Aromaticity0.103

Similar Structure Search

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