Basic Information

IDDRAMP01261
SequenceGLWSKIKEAAKTAGLMAMGFVNDMV
Length25
NameDermadistinctin-Q2 (DD Q2; Frogs, amphibians, animals)
SourcePhyllomedusa distincta (Monkey frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
PathogenGram-positive bacteria: Staphylococcus aureus (MIC=22 µM), Enterococcus faecalis (MIC=11 µM);##Gram-negative bacteria: Pseudomonas aeruginosa (MIC=22 µM), Escherichia coli (MIC=5.6 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.10477123]To produce hemolysis more than 38 μM peptide concentrations was required.
N-terminal ModificationFree
C-terminal ModificationFree
Linear/Cyclic/BranchedLinear
Uniprot P83642
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10477123

Physicochemical Properties

Residues25
SequenceGLWSKIKEAAKTAGLMAMGFVNDMV
Molecular Weight2669.189
Grand Average of Hydropathy0.416
Isoelectric Point8.498
Charge at pH 7.40.552
Secondary StructureHelix: 0.280, Turn: 0.200, Sheet: 0.400
Instability Index17.216
Aromaticity0.08

Similar Structure Search

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