Basic Information

IDDRAMP01422
SequenceGLLSGVLGVGKKVLCGLSGLC
Length21
NameNigrosin-OG21 (Frogs, amphibians, animals)
SourceOdorrana grahami (Yunnanfu frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacterium: Escherichia coli (MIC=4.68 µg/ml);##Gram-positive bacteria: Staphylococcus aureus (MIC=9.37 µg/ml), Bacillus subtilis (MIC=18.75 µg/ml).##Yeast: Candida albicans (MIC=4.68 µg/ml).
Hemolytic Activity[Ref.17272268] RCH=100% against rabbit red blood cells at 50 μg/ml. RCH, red cell hemolysis.
CytotoxicityNo cytotoxicity information found
N-terminal ModificationFree
C-terminal ModificationCyclization (Cys15 and Cys21)
Linear/Cyclic/BranchedCyclic
Uniprot
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID17272268

Physicochemical Properties

Residues21
SequenceGLLSGVLGVGKKVLCGLSGLC
Molecular Weight1973.447
Grand Average of Hydropathy1.362
Isoelectric Point8.904
Charge at pH 7.41.503
Secondary StructureHelix: 0.429, Turn: 0.381, Sheet: 0.286
Instability Index-2.605
Aromaticity0

Similar Structure Search

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