Basic Information

IDDRAMP01671
SequenceALWMTLLKKVLKAAAKALNAVLVGANA
Length27
NameDermaseptin-4 (DS IV; Dermaseptin-S4, DS4; Frogs, amphibians, animals)
SourcePhyllomedusa sauvagei (Sauvage's leaf frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antiviral
Pathogen[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1
Hemolytic Activity[Ref:11850249]IC50=20 μM against human erythrocytes
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P80280
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8306981, 11850249, 9395500

Physicochemical Properties

Residues27
SequenceALWMTLLKKVLKAAAKALNAVLVGANA
Molecular Weight2779.433
Grand Average of Hydropathy1.004
Isoelectric Point10.478
Charge at pH 7.43.598
Secondary StructureHelix: 0.370, Turn: 0.111, Sheet: 0.556
Instability Index10.381
Aromaticity0.037

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