Basic Information

IDDRAMP18708
SequenceALWMTLLKKVLKAAAKAALNAVLVGANA
Length28
NameDermaseptin-S4 (DRS-S4, DS4; frog, amphibians, animals)
SourcePhyllomedusa sauvagei (Sauvage's leaf frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
Pathogen[Swiss_Prot Entry P80280]Possesses a potent antimicrobial activity against Gram-negative and Gram-positive bacteria, fungi, protozoa, and the enveloped herpes simplex virus type 1
Hemolytic Activity[Swiss_Prot Entry P80280]Strong hemolytic activity
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P80280
PDB 2DD6 resolved by NMR
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID8306981

Physicochemical Properties

Residues28
SequenceALWMTLLKKVLKAAAKAALNAVLVGANA
Molecular Weight2850.51
Grand Average of Hydropathy1.032
Isoelectric Point10.478
Charge at pH 7.43.598
Secondary StructureHelix: 0.357, Turn: 0.107, Sheet: 0.571
Instability Index10.368
Aromaticity0.036

Similar Structure Search

Candidates based on structure

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