Basic Information

IDDRAMP01697
SequenceGMWSKIKNAGKAAKAAAKAAGKAALGAVSEAM
Length32
NameDermaseptin-DA4 (DRS-DA4; Frogs, amphibians, animals)
SourcePachymedusa dacnicolor (Mexican frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram-
Pathogen[Ref.FEBS J. 2009 Nov;276(22):6773-6786.]Gram-negative bacteria:Escherichia coli ML35p(MIC=5 µM), Escherichia coli 363 ATCC 11775(MIC=5 µM), Peudomonas aeruginosa ATCC 27853(MIC=40 µM).
Hemolytic Activity[Ref. FEBS J. 2009 Nov;276(22):6773-6786.]Show no hemolytic activity against rat blood cells.
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed IDPubMed ID is not available

Physicochemical Properties

Residues32
SequenceGMWSKIKNAGKAAKAAAKAAGKAALGAVSEAM
Molecular Weight3059.608
Grand Average of Hydropathy0.106
Isoelectric Point10.302
Charge at pH 7.44.544
Secondary StructureHelix: 0.125, Turn: 0.219, Sheet: 0.500
Instability Index2.441
Aromaticity0.031

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