| ID | DRAMP03138 |
|---|---|
| Sequence | GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL |
| Length | 34 |
| Name | Cecropin-A (Insects, animals) |
| Source | Aedes aegypti (Yellowfever mosquito) |
| Activity | Antimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal |
| Pathogen | Gram-negative bacteria: Escherichia coli D22 (MIC=0.25-0.5 µg/ml), E. coli D31 (MIC=0.25-0.5 µg/ml), E. coli SBS363 (MIC=0.1-0.25 µg/ml), E. coli 1106 (MIC=0.25-0.5 µg/ml), Enterobacter cloacae b12 (MIC=50-100 µg/ml), E. carotovora (MIC=0.25-0.5 µg/ml), Klebsiella pneumoniae (MIC=1-2.5 µg/ml), Pseudomonas aeruginosa (MIC=10-25 µg/ml), Salmonella typhimurium (MIC=1-2.5 µg/ml), X. campestris (MIC=0.5-1 µg/ml);##Gram-positive bacteria: Aerococcus viridans (MIC=2.5-5 µg/ml), Bacillus megaterium (MIC=1-2.5 µg/ml), Micrococcus luteus (MIC=10-25 µg/ml), Streptococcus pyogenes (MIC=10-25 µg/ml).##Fungi: Fusarium culmorum (MIC=1-2.5 µg/ml), Fusarium oxysporum (MIC=2.5-5 µg/ml), Neurospora crassa (MIC=5-10 µg/ml), Candida albicans (MIC=25-50 µg/ml), Cryptococcus neoformans (MIC=25-50 µg/ml), Saccharomyces cerevisiae (MIC=50-100 µg/ml) |
| Hemolytic Activity | No hemolysis information or data found in the reference(s) presented in this entry |
| Cytotoxicity | Not included yet |
| N-terminal Modification | Not included yet |
| C-terminal Modification | Not included yet |
| Linear/Cyclic/Branched | Not included yet |
| Uniprot | P82592, Q17NR3, Q95PI9 |
| PDB | |
| 3D View | |
| PDB Download | Download PDB Predicted by Alphafold2 |
| PubMed ID | 10400619 |
Physicochemical Properties
| Residues | 34 |
|---|---|
| Sequence | GGLKKLGKKLEGAGKRVFNAAEKALPVVAGAKAL |
| Molecular Weight | 3391.061 |
| Grand Average of Hydropathy | 0.021 |
| Isoelectric Point | 10.391 |
| Charge at pH 7.4 | 5.542 |
| Secondary Structure | Helix: 0.265, Turn: 0.235, Sheet: 0.412 |
| Instability Index | 16.774 |
| Aromaticity | 0.029 |