Basic Information

IDDRAMP03140
SequenceGRLKKLGKKIEGAGKRVFKAAEKALPVVAGVKALG
Length35
NameAnopheles cecropin-A amidated isoform (Insects, animals)
SourceAnopheles gambiae (African malaria mosquito)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal
PathogenGram-negative bacteria: Alcaligenes faecalis (MIC=1-2.5 µM), Escherichia coli 1106 (MIC=0.5-1 µM), E. coli D22 (MIC=0.1-0.25 µM), E. coli D31 (MIC=0.1-0.25 µM), E. coli SBS363 (MIC=0.05-0.1 µM), Enterobacter cloacae β12 (MIC=0.5-1 µM), Erwinia carotovora (MIC=0.5-1 µM), Klebsiella pneumoniae (MIC=1-2.5 µM), Pseudomonas aeruginosa (MIC=1-2.5 µM), Salmonella typhimurium (MIC=0.1-0.25 µM), Xanthomonas campestris (MIC=0.5-1 µM); ##Gram-positive bacteria: Aerococcus viridans (MIC=0.5-1 µM), Bacillus cereus (MIC=50-100 µM), Bacillus megaterium (MIC=0.5-1 µM), Listeria monocytogenes (MIC=50-100 µM), Micrococcus luteus (MIC=0.5-1 µM), Staphylococcus aureus (MIC=50-100 µM), Staphylococcus epidermidis (MIC=10-25 µM), Staphylococcus haemolyticus (MIC=1-2.5 µM), Staphylococcus saprophyticus (MIC=1-2.5 µM), Streptococcus pyogenes (MIC=0.1-0.25 µM).##Fungi: Aspergillus fumigatus (MIC=5-10 µM), Botrytis cinerea (MIC=1-2.5 µM), Fusarium culmorum (MIC=0.5-1 µM), Fusarium oxysporum (MIC=1-2.5 µM), Neurospora crassa (MIC=1-2.5 µM), Candida albicans (MIC=1-2.5 µM), Cryptococcus neoformans (MIC=5-10 µM), Saccharomyces cerevisiae (MIC=25-50 µM).
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P82290, A7XAX5, A7XAX7, A7XAY1, A7XAY8, A7XAZ7, A7XB12, A7XB23, Q7QEE3
PDB
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PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID10672074, 12421409

Physicochemical Properties

Residues35
SequenceGRLKKLGKKIEGAGKRVFKAAEKALPVVAGVKALG
Molecular Weight3589.369
Grand Average of Hydropathy-0.031
Isoelectric Point10.79
Charge at pH 7.47.54
Secondary StructureHelix: 0.286, Turn: 0.200, Sheet: 0.343
Instability Index22.917
Aromaticity0.029

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Candidates based on structure

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