Basic Information

IDDRAMP01730
SequenceFLPLIGRVLSGIL
Length13
NameTemporin-A (Frogs, amphibians, animals)
SourceRana temporaria (European common frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-
Pathogen[Ref.9022710] Gram-positive bacteria: Bacillus megaterium BM11 (LC=1.2 µM), Staphylococcus aureus Cowan 1 (LC=2.3 µM), Streptococcus pyogenes betahemolytic group A (LC=2.0 µM);##Gram-negative bacteria: Escherichia coli D21 (LC=11.9 µM), Escherichia coli D21e7 (LC=1.4 µM), Escherichia coli D21f1 (LC=0.9 µM), Escherichia coli D21f2 (LC=4.8 µM), Escherichia coli D22 (LC=3.4 µM), Yersinia pseudotuberculosis (LC=2.0 µM), Pseudomonas aeruginosa ATCC 15692 (LC>360 µM);##Yeast: Candida albicans ATCC 10261 (LC=3.4 µM).(LC: Lethal concentration)
Hemolytic Activity[Ref.9022710] LC>120 µM against Human red blood cells. (LC: Lethal concentration)
CytotoxicityNot included yet
N-terminal ModificationNot included yet
C-terminal ModificationNot included yet
Linear/Cyclic/BranchedNot included yet
Uniprot P56917
PDB 2MAA
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID9022710

Physicochemical Properties

Residues13
SequenceFLPLIGRVLSGIL
Molecular Weight1397.746
Grand Average of Hydropathy1.808
Isoelectric Point9.75
Charge at pH 7.40.557
Secondary StructureHelix: 0.615, Turn: 0.308, Sheet: 0.308
Instability Index32.331
Aromaticity0.077

Similar Structure Search

Candidates based on structure

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