Basic Information

IDDRAMP29055
SequenceFFPVIGRILNGIL
Length13
Nametemporin G
SourceRana temporaria (European common frog)
ActivityAntimicrobial, Antibacterial, Anti-Gram+, Anti-Gram-, Antifungal, Antibiofilm
Pathogen[Ref.33321906] S. aureus ATCC 25923 biofilm: TG was capable of killing at least 39%, 78% and 87% at 3.12, 6.25, 12.5 and 25 µM. ##[Ref.22439858] Summary: TG had specific bactericidal activities against E. coli ATCC2592, M. luteus or S. cerevisiae.
Hemolytic ActivityNo hemolysis information or data found in the reference(s) presented in this entry
Cytotoxicity[Ref.33321906]TG was shown to be harmless against human keratinocytes at all concentrations tested with a slight cytotoxicity (~20% reduction of metabolically-active cells) at the highest active concentration
N-terminal ModificationFree
C-terminal ModificationAmidation
Linear/Cyclic/BranchedLinear
Uniprot P79875
PDB
3D View
PDB DownloadDownload PDB Predicted by Alphafold2
PubMed ID33321906, 22439858

Physicochemical Properties

Residues13
SequenceFFPVIGRILNGIL
Molecular Weight1458.788
Grand Average of Hydropathy1.577
Isoelectric Point9.75
Charge at pH 7.40.557
Secondary StructureHelix: 0.615, Turn: 0.308, Sheet: 0.154
Instability Index50.4
Aromaticity0.154

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